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While the litigation over the 691 patent was pending, Ortho-McNeil surrendered the 691 patent and requested a reissue from the USPTO.
In an anticipation context, this consisting of language would prevent the 589 patents four-agent formulations from reading on the two-agent formulations claimed in the 221 patent. Both opinions rely on US Patent No 3,652,589 pdf file, which discloses various embodiments of a four-agent tablet that includes acetaminophen and tramadol as two of the active ingredients as tramadol ultram 50mg along.
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